{"id":5792,"date":"2025-07-22T13:58:07","date_gmt":"2025-07-22T08:58:07","guid":{"rendered":"https:\/\/vetnewsandviews.com\/en\/?p=5792"},"modified":"2026-03-14T16:26:57","modified_gmt":"2026-03-14T11:26:57","slug":"the-silent-impact-of-circadian-rhythms-on-drug-absorption-and-efficacy","status":"publish","type":"post","link":"https:\/\/vetnewsandviews.com\/en\/the-silent-impact-of-circadian-rhythms-on-drug-absorption-and-efficacy\/","title":{"rendered":"The silent impact of circadian rhythms on drug absorption and efficacy"},"content":{"rendered":"

Mahrukh Babar<\/strong><\/p>\n

Department of Pharmacy, Abasyn University, Islamabad, Pakistan<\/p>\n

Corresponding author: <\/strong>mahrukh.babar@abasynisb.edu.pk<\/a><\/p>\n

\"How<\/p>\n

Introduction: The human body functions on a 24 hour circadian rhythms. These circadian rhythms are regulated by recurring day\/night cycles, enable living things to anticipate and effectively react to a dynamically changing physiological events such as sleep, hormone secretions and even drug absorption and metabolism (Reddy et al., 2018). This rhythmic event significantly affect pharmacokinetic properties of drugs, how they are absorbed, distributed, metabolized and excreted out from the body (Mauvoisin et al., 2014).<\/p>\n

Absorption of drugs depend on physiological processes of administration. Key transporters are expressed in such a way that their levels reach peak level at specific time of the day (Dong et al., 2020). For example, medications taken at night are metabolized differently then take in the morning, effecting its efficacy and safety profile. Chronopharmacology is an important discipline in this regard which helps us understand how circadian rhythms can optimize therapeutic outcomes of drugs by reducing their side effects and enhance their efficacy.<\/p>\n

This field has shown promising results in hypertension, stress management, rheumatoid arthritis and asthma where symptoms severity varies by time of the day (Ohdo et al., 2007). For instance, a recent study of children with asthma who received theophylline at either 06:00 or 21:00 revealed that the drug’s serum levels were doubled when the dose was given at 21:00. Additionally, this nightly dosage schedule coincided with the natural dyspnea cycle, peaking during the most severe symptoms (Dallmann et al., 2014).<\/p>\n

Conclusion<\/h2>\n

By aligning body\u2019s rhythms with drug treatments, better therapeutic outcomes can be obtained with reduced toxicity. Despite all these benefits, chronopharmacology is not integrated widely in clinical practice and needs more patient specific research on drug-time data. Also there is a need for awareness among physicians about the power of body clock in pharmacotherapy.<\/p>\n

References:<\/h2>\n

1.\u00a0\u00a0\u00a0\u00a0\u00a0 Dallmann, R., Brown, S. A., & Gachon, F. (2014). Chronopharmacology: new insights and therapeutic implications.\u00a0Annual review of pharmacology and toxicology<\/i>,\u00a054<\/i>, 339-361.<\/p>\n

2.\u00a0\u00a0\u00a0\u00a0\u00a0Dong, D., Yang, D., Lin, L., Wang, S., & Wu, B. (2020). Circadian rhythm in
\npharmacokinetics and its relevance to chronotherapy.\u00a0Biochemical
\nPharmacology<\/i>,\u00a0178<\/i>, 114045.<\/p>\n

3.\u00a0 \u00a0 \u00a0 \u00a0Mauvoisin, D,Wang, J, Jouffe, C., Martin, E., Atger, F., Waridel, P., & Naef, F.
\n(2014). Circadian clock-dependent and-independent rhythmic proteomes implement
\ndistinct diurnal functions in mouse liver.\u00a0Proceedings of the National
\nAcademy of Sciences<\/i>,\u00a0111<\/i>, 167-172.<\/p>\n

4.\u00a0\u00a0\u00a0\u00a0\u00a0 Ohdo, S. (2007). Chronopharmacology focused on biological clock.\u00a0Drug metabolism and pharmacokinetics<\/i>,\u00a022<\/i>(1), 3-14.<\/p>\n

5.\u00a0\u00a0\u00a0\u00a0\u00a0 Reddy, S., Reddy, V., & Sharma, S. (2018). Physiology, circadian rhythm.<\/p>\n

\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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